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α-MSH TFA (α-Melanocyte-Stimulating Hormone) is an endogenous neuropeptide and a melanocortin receptor 4 (MC4R) agonist. It exhibits anti-inflammatory and antipyretic activities and is a post-translational derivative of pro-opiomelanocortin (POMC).
Endogenous neuropeptide
Acts as a melanocortin receptor 4 (MC4R) agonist
Exhibits anti-inflammatory activities
Exhibits antipyretic activities
Modulates central nervous system inflammation by acting directly on melanocortin receptors in glial cells
Modulates NFκB activation and inhibits translocation of transcription factor κB to the nucleus
Effective in modulating inflammatory reactions in vivo
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